Taurine deficiency is a cause of vigabatrin-induced retinal phototoxicity
نویسندگان
چکیده
منابع مشابه
The Vigabatrin Induced Retinal Toxicity is Associated with Photopic Exposure and Taurine Deficiency: An In Vivo Study.
BACKGROUND/AIMS Retinal toxicity is one of the most commonly discussed and concerning adverse effects of vigabatrin (VGB). The present study explored the relationship between the VGB elicited retinal toxicity, photopic exposure, and taurine deficiency, aiming at screening for risk factors to minimize the adverse effects of VGB. METHODS The effects of VGB on function and morphology of mouse re...
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Vigabatrin (VGB) is a commonly prescribed antiepileptic drug designed to inhibit GABA-transaminase, effectively halting seizures. Unfortunately, VGB treatment is also associated with the highest frequencies of peripheral visual field constriction of any of the antiepileptic drugs and the mechanisms that lead to these visual field defects are uncertain. Recent studies have demonstrated light exp...
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متن کاملAtrophic Cardiac Remodeling Induced by Taurine Deficiency in Wistar Rats
INTRODUCTION Micronutrient deficiency is observed in heart failure patients. Taurine, for example, represents 50% of total free amino acids in the heart, and in vivo studies have linked taurine deficiency with cardiomyopathy. METHODS Thirty-four male Wistar rats (body weight = 100 g) were weighed and randomly assigned to one of two groups: Control (C) or taurine-deficient (T (-)). Beta-alanin...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2009
ISSN: 0364-5134,1531-8249
DOI: 10.1002/ana.21526